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LGI1 Antibody: RPE

Mouse Anti-Mouse LGI1 Monoclonal IgG2a

Product Specifications

Background

The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist; this LGI1 antibody will recognize only the longer form.

Specifications

Detects ~60kDa.

Product Name Alternative

ADLTE Antibody, ADPAEF Antibody, ADPEAF Antibody, Epitempin 1 Antibody, EPT Antibody, ETL1 Antibody, IB1099 Antibody, leucine rich glioma inactivated 1 Antibody, OTTHUMP00000020121 Antibody, OTTHUMP00000020122 Antibody

Synonyms

LGI1 Antibody, Clone N283/7: RPE

UNSPSC

12352203

Gene ID

56839

Swiss Prot

Q9JIA1.1

Accession Number

NP_064674.1

Cellular Locus

Cell Junction | Golgi Apparatus | Endoplasmic Reticulum

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1. Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ~50% identity with LGI2, LGI3 and LGI4.

Target

LGI1

Clonality

Monoclonal

Isotype

IgG2a

Clone

N283/7 (Formerly sold as S283-7)

Conjugation

RPE

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-461 was sufficient for detection of LGI1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Chernova O.B., Somerville R.P. and Cowell J.K. (1998) Oncogene. 17:2873-81. 2. Fialka F., et al. (2008) Oral Oncol. 3. Gu W., et al. (2005) Mol. Biol. Evol. 22:2209-16. 4. Fukata Y., et al. (2006) Science. 313:1792-5.

Product Datasheet

https://cdn.gentaur.com/products/400/4292067/datasheet/smc-461d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4292067/msds/smc-461d-rpe.pdf

CAS Number

9007-83-4

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