Mitofusin 2 Antibody
Mouse Anti-Human Mitofusin 2 Monoclonal IgG2a
Product Specifications
Background
Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.
Specifications
Detects ~90kDa. No cross-reactivity against Mitofusin-1.
Product Name Alternative
CMT2A Antibody, CMT2A2 Antibody, CPRP 1 Antibody, CPRP1 Antibody, Fzo Antibody, HSG Antibody, hyperplasia suppressor gene Antibody, Hypertension related protein 1 Antibody, KIAA0214 Antibody, MARF Antibody, MFN 2 Antibody, Mfn2 Antibody, Mitochondrial assembly regulatory factor Antibody, Mitofusin-2 Antibody, Mitofusin2 Antibody, Transmembrane GTPase MFN2 Antibody
Synonyms
Mitofusin 2 Antibody, Clone N153/5
UNSPSC
12352203
Gene ID
170731
Swiss Prot
Q80U63
Accession Number
NP_573464.2
Cellular Locus
Mitochondrion | Mitochondrion Outer Membrane
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.
Target
Mitofusin 2
Clonality
Monoclonal
Isotype
IgG2a
Clone
N153/5 (Formerly sold as S153-5)
Conjugation
Unconjugated
Validated Applications
WB,IHC,ICC/IF
Purification
Protein G Purified
Limit Of Detection
1 µg/ml of SMC-457 was sufficient for detection of Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Product MSDS
https://cdn.gentaur.com/products/400/4292019/msds/smc-457s.pdf
CAS Number
9007-83-4
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