VDAC1 Antibody
Mouse Anti-Human VDAC1 Monoclonal IgG2a
Product Specifications
Background
Voltage-dependent anion-selective channel protein 1 (also known as VDAC, VDAC1 or outer mitochondrial membrane protein porin 1) is the the outer mitochondrial membrane receptor for hexokinase and BCL2L1. VDAC forms a channel through the mitochondrial membrane and is involved in small molecule diffusion, cell volume regulation and apoptosis. VDAC may participate in the formation of the permeability transition pore complex (PTPC), which is responsible for the release of mitochondrial products that triggers apoptosis.
Specifications
Detects ~30kDa. Does not cross-react with VDAC2 or VDAC3 (based on KO validation results).
Product Name Alternative
Voltage Dependent Anion Channel 1 Antibody, Porin Antibody, Voltage dependent anion selective channel protein 1 Antibody, Voltage-dependent anion-selective channel protein 1 Antibody, hVDAC1 Antibody, MGC111064 Antibody, Mitochondrial Porin Antibody, Outer mitochondrial membrane protein porin 1 Antibody, Plasmalemmal porin Antibody, Porin 31HL Antibody, Porin 31HM Antibody, PORIN-31-HL Antibody, VDAC 1 Antibody, VDAC Antibody, VDAC-1 Antibody
Synonyms
VDAC1 Antibody, Clone N152B/23
UNSPSC
12352203
Gene ID
7416
Swiss Prot
P21796
Accession Number
NP_003365.1.
Cellular Locus
Mitochondrion | Mitochondrion Outer Membrane | Cell Membrane
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein amino acids 1-283 (full-length) of human VDAC1. Mouse: 98% identity (279/283 amino acids identical). Rat: 98% identity (279/283 amino acids identical) >60% identity with VDAC2 and VDAC3.
Target
VDAC1
Clonality
Monoclonal
Isotype
IgG2a
Clone
N152B/23 (Formerly sold as S152B-23)
Conjugation
Unconjugated
Validated Applications
WB,IHC,ICC/IF
Purification
Protein G Purified
Limit Of Detection
1 µg/ml of SMC-456 was sufficient for detection of VDAC1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000); optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Product MSDS
https://cdn.gentaur.com/products/400/4291994/msds/smc-456s.pdf
CAS Number
9007-83-4
Curated Selection
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