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VDAC1 Antibody: ATTO 390

Mouse Anti-Human VDAC1 Monoclonal IgG2a

Product Specifications

Background

Voltage-dependent anion-selective channel protein 1 (also known as VDAC, VDAC1 or outer mitochondrial membrane protein porin 1) is the the outer mitochondrial membrane receptor for hexokinase and BCL2L1. VDAC forms a channel through the mitochondrial membrane and is involved in small molecule diffusion, cell volume regulation and apoptosis. VDAC may participate in the formation of the permeability transition pore complex (PTPC), which is responsible for the release of mitochondrial products that triggers apoptosis.

Specifications

Detects ~30kDa. Does not cross-react with VDAC2 or VDAC3 (based on KO validation results).

Product Name Alternative

Voltage Dependent Anion Channel 1 Antibody, Porin Antibody, Voltage dependent anion selective channel protein 1 Antibody, Voltage-dependent anion-selective channel protein 1 Antibody, hVDAC1 Antibody, MGC111064 Antibody, Mitochondrial Porin Antibody, Outer mitochondrial membrane protein porin 1 Antibody, Plasmalemmal porin Antibody, Porin 31HL Antibody, Porin 31HM Antibody, PORIN-31-HL Antibody, VDAC 1 Antibody, VDAC Antibody, VDAC-1 Antibody, Antibody

Synonyms

VDAC1 Antibody, Clone N152B/23: ATTO 390

UNSPSC

12352203

Gene ID

7416

Swiss Prot

P21796

Accession Number

NP_003365.1.

Cellular Locus

Mitochondrion | Mitochondrion Outer Membrane | Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1-283 (full-length) of human VDAC1. Mouse: 98% identity (279/283 amino acids identical). Rat: 98% identity (279/283 amino acids identical) >60% identity with VDAC2 and VDAC3.

Target

VDAC1

Clonality

Monoclonal

Isotype

IgG2a

Clone

N152B/23 (Formerly sold as S152B-23)

Conjugation

ATTO 390

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-456 was sufficient for detection of VDAC1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Product Datasheet

https://cdn.gentaur.com/products/400/4291971/datasheet/smc-456d-a390.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4291971/msds/smc-456d-a390.pdf

CAS Number

9007-83-4

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