ATF4 Antibody

Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to amino acid deprivation.

Activating Transcription Factor 4 Antibody, ATF 4 Antibody, ATF4 protein Antibody, cAMP-dependent transcription factor ATF-4 Antibody, cAMP-responsive element-binding protein 2 Antibody, CREB 2 Antibody, CREB-2 Antibody, CREB2 Antibody, Cyclic AMP dependent transcription factor ATF 4 Antibody, Cyclic AMP response element binding protein 2 Antibody, Cyclic AMP response element binding protein 2 Antibody, Cyclic AMP-dependent transcription factor ATF-4 Antibody, Cyclic AMP-responsive element-binding protein 2 Antibody, DNA binding protein TAXREB67 Antibody, DNA binding protein TAXREB67 Antibody, DNA-binding protein TAXREB67 Antibody, Tax Responsive Enhancer Element B67 Antibody, Tax-responsive enhancer element-binding protein 67 Antibody, TAXREB67 Antibody, TXREB Antibody

1 µg/ml of SMC-447 was sufficient for detection of ATF4 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.