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LRRK2/Dardarin Antibody

Mouse Anti-Human LRRK2/Dardarin Monoclonal IgG2a

Product Specifications

Background

LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.

Specifications

Detects >200kDa.

Product Name Alternative

Leucine-rich repeat kinase 2 Antibody, RIP7 Antibody, PARK8 Antibody, Dardarin Antibody, ROCO 2 Antibody, RIPK7 Antibody, Leucine-rich repeat serine/threonine-protein kinase 2 Antibody, augmented in rheumatoid arthritis 17 Antibody

Synonyms

LRRK2/Dardarin Antibody, Clone N231B/34

UNSPSC

12352203

Gene ID

120892

Swiss Prot

Q5S007

Accession Number

NP_940980

Cellular Locus

Cytoplasm | Membrane | Mitochondrion | Golgi Apparatus | Cell Projection | Axon | Dendrite | Endoplasmic Reticulum | Cytoplasmic Vesicle | Endosome | Lysosome

Host

Mouse

Species Reactivity

Human,Rat

Immunogen

Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.

Target

LRRK2

Clonality

Monoclonal

Isotype

IgG2a

Clone

N231B/34 (Formerly sold as S231B-34)

Conjugation

Unconjugated

Validated Applications

WB,ICC/IF,IHC

Purification

Protein G Purified

Limit Of Detection

10 µg/ml of SMC-445 was sufficient for detection of LRRK2/Dardarin in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Product MSDS

https://cdn.gentaur.com/products/400/4291695/msds/smc-445d.pdf

CAS Number

9007-83-4

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