GluA1 Antibody, Clone N355/1

Mouse Anti-Rat GluA1 (Glutamate Receptor 1) Monoclonal IgG1

Product Specifications

Background

GluR1, also known as glutamate receptor 1 or GRIA1, is an integral membrane protein and a subunit of AMPA-type ionotropic glutamate receptors. These receptors mediate fast excitatory neurotransmission in the central nervous system and are essential for synaptic plasticity, learning, and memory. GluR1 is widely expressed in the human brain and plays a central role in postsynaptic responses to glutamate—the primary excitatory neurotransmitter in mammals. While originally associated with kainate binding, GluR1 is now recognized as a core component of AMPA receptors, which are activated by glutamate and modulated by auxiliary proteins. Dysregulation of GluR1 expression, trafficking, or phosphorylation has been implicated in several neurodegenerative and neuropsychiatric disorders, including Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and schizophrenia. Aberrant GluR1 signaling can lead to excitotoxicity, synaptic dysfunction, and neuronal loss—hallmarks of neurodegeneration. Given its critical role in maintaining synaptic integrity and plasticity, GluR1 is a valuable target for therapeutic intervention and a potential biomarker for disease progression in neurodegenerative research.

CAS Number

9007-83-4

Specifications

Detects ~100kDa. Does not cross-react with GluR2.

Product Name Alternative

2900051M01Rik, AI853806, AMPA 1, AMPA selective glutamate receptor 1, GLUH 1, GLUH1, GLUR1, GLURA, Glr-1, Glr1, GluA1, GluR K1, GluR-A, GluR1, GluRA, GluRK1, Glur-1, Glur1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Gria 1, HBGR1, HIPA, MGC13325, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, gluR-

Synonyms

GluA1/GluR1 Antibody, Clone N355/1

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

50592

Swiss Prot

P19490

Accession Number

NP_113796

Cellular Locus

Cell Membrane | Endoplasmic Reticulum | Cell Junction

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1

Target

GluR1

Clonality

Monoclonal

Isotype

IgG1

Clone

N355/1

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | IHC | ICC/IF

Validated Applications

WB,IHC,ICC/IF

Field of Research

Neuroscience | Neurotransmitter Receptors | (Glutamate Receptor 1) s | AMPA Receptors | Cell Signaling

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-440 was sufficient for detection of GluA1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~100kDa. Does not cross-react with GluR2.

Background Reference 01

1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2 (4) : 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88 (17) : 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.