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GluA1/GluR1 Antibody: FITC

Mouse Anti-Rat GluA1/GluR1 Glutamate Receptor Monoclonal IgG1

Product Specifications

Background

Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3).

Specifications

Detects ~100kDa. Does not cross-react with GluR2.

Product Name Alternative

AMPA 1 Antibody, AMPA selective glutamate receptor 1 Antibody, Glutamate receptor 1 Antibody, GluA1 Antibody, GLUH 1 Antibody, GluR K1 Antibody, GluRK1 Antibody, Glr-1 Antibody, Glur-1 Antibody, HIPA Antibody, Glur1 Antibody, GluR-A Antibody, AI853806 Antibody, 2900051M01Rik Antibody, GluRA Antibody, Glr1 Antibody, MGC13325 Antibody, GLUH1 Antibody, GluA1 Antibody, GLUR1 Antibody, HBGR1 Antibody, GLURA Antibody, gluR- Antibody, GluA1 Antibody, Glutamate receptor ionotropic AMPA 1 Antibody, Glutamate receptor ionotropic Antibody, Gria 1 Antibody, HBGR1 Antibody, OTTHUMP00000160643 Antibody, OTTHUMP00000165781 Antibody, OTTHUMP00000224241 Antibody, OTTHUMP00000224242 Antibody, OTTHUMP00000224243 Antibody

Synonyms

GluA1/GluR1 Antibody, Clone N355/1: FITC

UNSPSC

12352203

Gene ID

50592

Swiss Prot

P19490

Accession Number

NP_113796

Cellular Locus

Cell Membrane | Endoplasmic Reticulum | Cell Junction

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1

Target

GluR1

Clonality

Monoclonal

Isotype

IgG1

Clone

N355/1 (Formerly sold as S355-1)

Conjugation

FITC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-440 was sufficient for detection of GluA1/GluR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.

Product Datasheet

https://cdn.gentaur.com/products/400/4291588/datasheet/smc-440d-fitc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4291588/msds/smc-440d-fitc.pdf

CAS Number

9007-83-4

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