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SUR2A Antibody: Biotin

Mouse Anti-Mouse SUR2A Monoclonal IgG2A

Product Specifications

Background

Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).

Specifications

Detects ~120kDa. Does not cross-react with SUR2B.

Product Name Alternative

ABCC9 Antibody, Sulfonylurea receptor 2 Antibody, CMD10 Antibody, ABC37 Antibody, ATP-binding cassette transporter sub-family C member 9 Antibody, Sulfonylurea receptor 2A Antibody, isoform SUR2A Antibody

Synonyms

SUR2A Antibody, Clone N319A/14: Biotin

UNSPSC

12352203

Gene ID

20928

Swiss Prot

P70170

Accession Number

NP_001038185.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1505-1546 (SSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK, cytoplasmic C-terminus) of mouse SUR2A

Target

SUR2A

Clonality

Monoclonal

Isotype

IgG2A

Clone

N319A/14 (Formerly sold as S319A-14)

Conjugation

Biotin

Validated Applications

WB,IHC,ICC/IF |ELISA

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-431 was sufficient for detection of SUR2A in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, and 9.55mM Sodium Bicarbonate in 95.45% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Campbell J.D., Sansom M.S., Ashcroft F.M. (2003) EMBO Resp. 4(11): 1038-1042. 2. Nichols C.G. (2006) Nature. 440 (7083): 470-476.

Product Datasheet

https://cdn.gentaur.com/products/400/4291357/datasheet/smc-431d-bi.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4291357/msds/smc-431d-bi.pdf

CAS Number

9007-83-4

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