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Brevican Antibody: FITC

Mouse Anti-Rat Brevican Monoclonal IgG2B

Product Specifications

Background

Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.

Specifications

Detects ~140kDa (and smaller due to proteolytic cleavage).

Product Name Alternative

BCAN Antibody, BEHAB Antibody, CSPG7 Antibody, Brain enriched hyaluronan binding protein Antibody, Brevican core protein Antibody, Brevican core protein isoform 1 Antibody, Brevican core protein isoform 2 Antibody, Brevican proteoglycan Antibody, Chondroitin sulfate proteoglycan 7 Antibody, Chondroitin sulfate proteoglycan BEHAB Antibody, MGC13038 Antibody

Synonyms

Brevican Antibody, Clone N294A/6: FITC

UNSPSC

12352203

Gene ID

25393

Swiss Prot

P55068

Accession Number

NP_001028837.1

Cellular Locus

Extracellular Space | Extracellular Matrix | Membrane | Lipid-Anchor | GPI-Anchor

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 219-655 of rat Brevican

Target

Brevican

Clonality

Monoclonal

Isotype

IgG2B

Clone

N294A/6 (Formerly sold as S294A-6)

Conjugation

FITC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-428 was sufficient for detection of Brevican in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Yamada H., Watanabe K., Shimonaka M. and Yamaguchi Y. (1994) J. Biol. Chem. 269: 10119-10126. 2. Yamada H., Watanabe K., Shimonaka M., Yamasaki M. and Yamaguchi Y. (1995) Biochem. Biophys. Res. Commun. 216: 957-963. 3. Rauch U., et al. (1997) Genomics 44: 15-21. 4. Zhang H., Kelly G., Zerillo C., Jaworski D.M. and Hockfield S. (1998) J. Neurosci. 7: 2370-2376. 5. Aspberg A., Adam S., Kostka G., Timpl R. and Heinegard D. (1999) J. Biol. Chem. 274: 20444-20449.

Product Datasheet

https://cdn.gentaur.com/products/400/4291288/datasheet/smc-428d-fitc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4291288/msds/smc-428d-fitc.pdf

CAS Number

9007-83-4

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