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TARP Gamma2/4/8 (Stargazin) Antibody: ATTO 488

Mouse Anti-Rat TARP Gamma2/4/8 (Stargazin) Monoclonal IgG2A

Product Specifications

Background

Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.

Specifications

Detects ~35-55kDa. Does not cross-react with TARPGamma3.

Product Name Alternative

CACNG2 Antibody, Calcium channel voltage dependent gamma subunit 2 Antibody, CaV gamma 2 Antibody, Ipr328 Antibody, MGC123981 Antibody, MGC138502 Antibody, MGC138504 Antibody, Voltage-dependent calcium channel gamma-2 subunit Antibody, Neuronal voltage-gated calcium channel gamma-2 subunit Antibody, Stargazin Antibody, Stg Antibody, Stargazer Antibody, TARP Antibody, TARP gamma-2 Antibody, Transmembrane AMPAR regulatory protein gamma-2 Antibody, AW060990 Antibody, B230105C07Rik Antibody, B930041E13Rik Antibody, Wag Antibody, Waggler Antibody

Synonyms

TARP Gamma2/4/8 (Stargazin) Antibody, Clone N245/36: ATTO 488

UNSPSC

12352203

Gene ID

84347

Swiss Prot

Q71RJ2

Accession Number

NP_445803.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2

Target

Stargazin

Clonality

Monoclonal

Isotype

IgG2A

Clone

N245/36 (Formerly sold as S245-36)

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-422 was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gill M.B., et al. (2011) J Neurosci. 31(18): 6928-6938. 2. Yu L. (2011) Neuroscience. 178: 13-20. 3. Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690. 4. Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977. 5. Letts V.A., et al. (1998) Nat Genet. 19: 340-34

Product Datasheet

https://cdn.gentaur.com/products/400/4291122/datasheet/smc-422d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4291122/msds/smc-422d-a488.pdf

CAS Number

9007-83-4

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