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Dicer Antibody: RPE

Mouse Anti-Mouse Dicer Monoclonal IgG1

Product Specifications

Background

Dicer is a member of the RNase III family that specifically cleaves double-stranded RNAs to generate microRNAs (miRNAs) (1). After long primary transcript pri-miRNAs are processed to stem-looped pre-miRNAs by Drosha (2), pre-miRNAs are transported to the cytoplasm and further processed by Dicer to produce 22-nucleotide mature miRNAs (3). The mature miRNA then becomes a part of the RNA-Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA (3)

Specifications

Detects ~215kDa.

Product Name Alternative

Dicer1 Antibody, DCR Antibody, DCR1 Antibody, DCR-1 Antibody, Double-strand-specific ribonuclease Antibody, Helicase with RNase motif Antibody, HERNA Antibody, Helicase MOI Antibody, KIAA0928 Antibody, Endoribonuclease Dicer Antibody

Synonyms

Dicer Antibody, Clone N167/7: RPE

UNSPSC

12352203

Gene ID

192119

Swiss Prot

Q8R418

Accession Number

NP_683750.2

Cellular Locus

Cytoplasm

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer

Target

Dicer

Clonality

Monoclonal

Isotype

IgG1

Clone

N167/7 (Formerly sold as S167-7)

Conjugation

RPE

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-416 was sufficient for detection of Dicer in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Hutvágner G. and Zamore P.D. (2002) Science 297: 2056-60. 2. Lee Y., et al. (2003) Nature 425: 415-9. 3. Diederichs S. and Haber, D.A. (2007) Cell 131: 1097-108.

Product Datasheet

https://cdn.gentaur.com/products/400/4290992/datasheet/smc-416d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4290992/msds/smc-416d-rpe.pdf

CAS Number

9007-83-4

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