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SUR1 Antibody

Mouse Anti-Rat SUR1 Monoclonal IgG1

Product Specifications

Background

Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).

Specifications

Detects ~160kDa. Does not cross-react with SUR2B.

Product Name Alternative

AM60008PU-N Antibody, ABC36 Antibody, Abcc8 Antibody, ATP binding cassette sub family C member 8 Antibody, HHF1 Antibody, HRINS Antibody, MRP8 Antibody, PHHI Antibody, SUR Antibody, SUR1 Antibody, Sulfonylurea receptor (hyperinsulinemia) Antibody, ATP binding cassette sub family C (CFTR/MRP) member 8 Antibody, ATP binding cassette transporter sub family C member 8 (1) Antibody, ATP-binding cassette sub-family C member 8 Antibody, HI Antibody, PHHI Antibody, Sulfonylurea receptor 1 Antibody, SUR1delta2 Antibody, TNDM2 Antibody

Synonyms

SUR1 Antibody, Clone N289/16

UNSPSC

12352203

Gene ID

25559

Swiss Prot

Q09429

Accession Number

NP_037171.2

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat,Hamster

Immunogen

Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1

Target

SUR1

Clonality

Monoclonal

Isotype

IgG1

Clone

N289/16 (Formerly sold as S289-16)

Conjugation

Unconjugated

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-409 was sufficient for detection of SUR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Campbell J.D., Sansom M.S., Ashcroft F.M. (2003) EMBO Resp. 4(11): 1038-1042. 2. Nichols C.G. (2006) Nature. 440 (7083): 470-476.

Product MSDS

https://cdn.gentaur.com/products/400/4290795/msds/smc-409d.pdf

CAS Number

9007-83-4

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