GABA-B Receptor 2 Antibody: APC

GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).

BcDNA:GH07312 Antibody, CG6706 Antibody, CT20836 Antibody, D GABA[[B]]R2 Antibody, D Gaba2 Antibody, FLJ36928 Antibody, G protein coupled receptor 51 Antibody, G-protein coupled receptor 51 Antibody, GAB B R2 Antibody, GABA B R2 Antibody, GABA B receptor 2 Antibody, GABA B RECEPTOR Antibody, GABA-B receptor 2 Antibody, GABA-B-R2 Antibody, GABA-BR2 Antibody, GABA[[B]]R2 Antibody, GABAB R2 Antibody, GABABR 2 Antibody, GABABR2 Antibody, GABB R2 Antibody, GABBR 2 Antibody, GABBR2 Antibody, GABR2_HUMAN Antibody, Gamma aminobutyric acid (GABA) B receptor 2 Antibody, Gamma aminobutyric acid B receptor 2 Antibody, Gamma aminobutyric acid GABA B receptor 2 Antibody, Gamma aminobutyric acid type B receptor subunit 2 Antibody, Gamma-aminobutyric acid type B receptor subunit 2 Antibody, Gb 2 Antibody, Gb2 Antibody, GH07312 Antibody, GPR 51 Antibody, GPR51 Antibody, GPRC 3B Antibody, GPRC3B Antibody, HG 20 Antibody, HG20 Antibody, HRIHFB2099 Antibody, Metabotropic GABA B receptor subtype 2 Antibody, OTTHUMP00000021776 Antibody, OTTHUMP00000063797 Antibody, R2 SUBUNIT Antibody

1 µg/ml of SMC-402 was sufficient for detection of GABA(B)R2 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

1. Jones K.A,. et al. (2000) Neuropsychopharmacology 23: S41-9. 2. Duthey B., et al. (2002) J Biol Chem. 277: 3236-41. 3. Kaupmann K., et al. (1997) Nature 386: 239-46.