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SNAT1 Antibody: APC

Mouse Anti-Rat SNAT1 Monoclonal IgG1

Product Specifications

Background

The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. The SNAT1 protein, also designated ATA1 or NAT2 is encoded by the human gene SLC38A1 which maps to chromosome 12q13.11. SNAT1 is responsible for the transport of glutamine, an intermediate in the synthesis of urea, and may be involved in the generation of glutamate in the retina. SNAT1 protein may be detected in some tissues such as heart, brain and placenta and expression levels are enriched in certain neuronal populations within the CNS. SNAT1 is not present in astrocytes.

Specifications

Detects ~50kDa.

Product Name Alternative

SLC38A1 Antibody, amino acids transporter A1 Antibody, ATA1 Antibody, NAT2 Antibody, sodium coupled neutral amino acids transporter 1 Antibody, Amino acid transporter system A1 Antibody, N-system amino acid transporter 2 Antibody, S38A1 Antibody, SAT1 Antibody, SNAT 1 Antibody, Solute carrier family 38 member 1 Antibody, System A amino acid transporter 1 Antibody, System N amino acid transporter 1 Antibody

Synonyms

SNAT1 Antibody, Clone N104/32: APC

UNSPSC

12352203

Gene ID

170567

Swiss Prot

Q9JM15

Accession Number

NP_620187.1

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1- 63 of rat SNAT1

Target

SLC38A1

Clonality

Monoclonal

Isotype

IgG1

Clone

N104/32 (Formerly sold as S104-32)

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-401 was sufficient for detection of SNAT1 in 20 µg of lysates from neocortical neurons cultured under amino acid starvation conditions and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Hatanaka T., et al. ( 2000) Biochim. Biophys. Acta 1467: 1-6. 2. Wang H., et al. (2000) Biochem. Biophys. Res. Commun. 273: 1175-1179. 3. Gu S., et al. (2001) J. Biol. Chem. 276: 24137-24144. 4. Freeman T.L., et al. (2002) Arch. Biochem. Biophys. 400: 215-222. 5. Palii S.S., et al. (2004) J. Biol. Chem. 279: 3463-3471. 6. Sidoryk M., et al. (2004) Neuroreport. 15: 575-578. Erratum in: 2004. Neuroreport. 15: 533. 7. Desforges,M., et al. (2006) Am. J. Physiol. Cell. Physiol. 290: 305-312.

Product Datasheet

https://cdn.gentaur.com/products/400/4290605/datasheet/smc-401d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4290605/msds/smc-401d-apc.pdf

CAS Number

9007-83-4

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