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Sodium-Iodide Symporter Antibody: RPE

Mouse Anti-Human Sodium-Iodide Symporter Monoclonal IgG1

Product Specifications

Background

The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and thyroxine (3).

Specifications

Detects ~97kDa, non-glycosylated version at 68kDa. Other minor bands associated with hNIS at 160kDa, and degradation products at ~30 kDa, and ~15kDa.

Product Name Alternative

NIS Antibody, SLC5A5 Antibody, solute carrier family 5 Antibody, Na (+)I(-) cotransporter Antibody

Synonyms

Sodium Iodide Symporter Antibody, Clone 14F: RPE

UNSPSC

12352203

Gene ID

6528

Swiss Prot

Q92911

Accession Number

NP_000444.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Mannose binding protein hNIS fusion (AA468-643)

Target

Sodium Iodide Symporter

Clonality

Monoclonal

Isotype

IgG1

Clone

14F

Conjugation

RPE

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-390 was sufficient for detection of hNIS in 20 µg of transfected COS-7 cell membrane lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Dai G., Levy O., Carrasco N. (1996) Nature. 379(6564): 458-460. 2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558. 3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255.

Product Datasheet

https://cdn.gentaur.com/products/400/4290342/datasheet/smc-390d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4290342/msds/smc-390d-rpe.pdf

CAS Number

9007-83-4

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