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TrpC5 Antibody: PerCP

Mouse Anti-Human TrpC5 Monoclonal IgG2b

Product Specifications

Background

Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is a subtype of the TRPC family of mammalian transient receptor potential ion channels. Homo-multimeric TRPC5 and hetero-multimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin (1). This activation probably plays a role in rheumatoid arthritis. It has also been recently found to be involved in the action on anaesthetics such as chloroform, halothane and propofol (2).

Specifications

Detects ~110kDa.

Product Name Alternative

Htrp5 Antibody, Short transient receptor potential channel 5 Antibody, TRP5 Antibody

Synonyms

TRPC5 Antibody, Clone N67/15: PerCP

UNSPSC

12352203

Gene ID

7224

Swiss Prot

Q9UL62

Accession Number

NP_036603.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide amino acids 827-845 of human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5)

Target

TRPC5

Clonality

Monoclonal

Isotype

IgG2b

Clone

N67/15 (Formerly sold as S67-15)

Conjugation

PerCP

Validated Applications

WB,IHC,ICC/IF,ELISA

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-344 was sufficient for detection of TrpC5 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Xu S.Z., et al. (2008) Nature 451(7174): 69-72. 2. Bahnasi Y.M., et al. (2008) Br J. Pharamcol. 153(7): 1505-1512.

Product Datasheet

https://cdn.gentaur.com/products/400/4290241/datasheet/smc-344d-pcp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4290241/msds/smc-344d-pcp.pdf

CAS Number

9007-83-4

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