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TrpC5 Antibody: ATTO 390

Mouse Anti-Human TrpC5 Monoclonal IgG2b

Product Specifications

Background

Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is a subtype of the TRPC family of mammalian transient receptor potential ion channels. Homo-multimeric TRPC5 and hetero-multimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin (1). This activation probably plays a role in rheumatoid arthritis. It has also been recently found to be involved in the action on anaesthetics such as chloroform, halothane and propofol (2).

Specifications

Detects ~110kDa.

Product Name Alternative

Htrp5 Antibody, Short transient receptor potential channel 5 Antibody, TRP5 Antibody

Synonyms

TRPC5 Antibody, Clone N67/15: ATTO 390

UNSPSC

12352203

Gene ID

7224

Swiss Prot

Q9UL62

Accession Number

NP_036603.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide amino acids 827-845 of human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5)

Target

TRPC5

Clonality

Monoclonal

Isotype

IgG2b

Clone

N67/15 (Formerly sold as S67-15)

Conjugation

ATTO 390

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-344 was sufficient for detection of TrpC5 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Xu S.Z., et al. (2008) Nature 451(7174): 69-72. 2. Bahnasi Y.M., et al. (2008) Br J. Pharamcol. 153(7): 1505-1512.

Product Datasheet

https://cdn.gentaur.com/products/400/4290221/datasheet/smc-344d-a390.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4290221/msds/smc-344d-a390.pdf

CAS Number

9007-83-4

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