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Nav1.8 Antibody: FITC

Mouse Anti-Rat Nav1.8 Monoclonal IgG2a

Product Specifications

Background

Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.

Specifications

Detects ~220kDa. No cross reactivity against other Nav channels.

Product Name Alternative

mPN3 antibody, Peripheral nerve sodium channel 3 antibody, Pn3 (gene name) antibody, PN3 antibody, Scn10a antibody, Sensory neuron sodium channel antibody, Sns (gene name) antibody, SNS antibody, Sodium channel protein type 10 subunit alpha antibody, Sodium channel protein type X alpha subunit antibody, Voltage-gated sodium channel alpha subunit Nav1.8 antibody

Synonyms

Nav1.8 Antibody, Clone S134: FITC

UNSPSC

12352203

Gene ID

29571

Swiss Prot

Q62968

Accession Number

NP_058943.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat,Monkey

Immunogen

Fusion protein amino acids 1724-1956 of rat Nav1.8

Target

Nav1.8

Clonality

Monoclonal

Isotype

IgG2a

Clone

S134

Conjugation

FITC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-342 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. 2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.

Product Datasheet

https://cdn.gentaur.com/products/400/4290188/datasheet/smc-342d-fitc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4290188/msds/smc-342d-fitc.pdf

CAS Number

9007-83-4

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