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GluN2B/NR2B Antibody: ATTO 488

Mouse Anti-Rat GluN2B/NR2B Monoclonal IgG2b

Product Specifications

Background

NR2B containing receptors have been implicated in synaptic plasticity, memory formation and pain modulation (1). Studies suggest that the NR2B subunit of glutamate receptors may be potential targets for relieving pain; NR2B may be a probable target for anti-nociceptive drugs, and may also be useful as analgesics (2).

Specifications

Detects ~166kDa. No cross-reactivity against NR2A.

Product Name Alternative

NMDAR2B Antibody, hNR3 Antibody, MGC142180 Antibody, glutamate receptor subunit epsilon-2 Antibody, NR3 Antibody

Synonyms

GluN2B/NR2B Antibody, Clone S59: ATTO 488

UNSPSC

12352203

Gene ID

24410

Swiss Prot

Q00960

Accession Number

NP_036706.1

Cellular Locus

Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B

Target

NR2B

Clonality

Monoclonal

Isotype

IgG2b

Clone

S59

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-337 was sufficient for detection of NR2B in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhuo M. (2009) Mol Brain. 2(1): 4 2. Gurwitz D, and Weizman A. (2002) Drug Discovery Today, 7(7): 403-406.

Product Datasheet

https://cdn.gentaur.com/products/400/4290047/datasheet/smc-337d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4290047/msds/smc-337d-a488.pdf

CAS Number

9007-83-4

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