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Cav beta 2 Antibody: HRP

Mouse Anti-Rat Cav beta 2 Monoclonal IgG1

Product Specifications

Background

Cav Beat subunits are involved in the transport of the pore forming alpha1 subunit to the plasma membrane (1). They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the pore-forming subunit to the target membrane (2, 3). They also determine the biophysical properties of the calcium channel (3).

Specifications

Detects ~78 kDa. No cross reactivity against Cavβ1, Cavβ3, Cavβ4.

Product Name Alternative

Cacnlb2 Antibody, cacnb2 Antibody, Voltage-dependent L-type calcium channel subunit beta-2 Antibody, CAB2 Antibody

Synonyms

CavBeta2 Antibody, Clone N8b/1: HRP

UNSPSC

12352203

Gene ID

116600

Swiss Prot

Q8VGC3

Accession Number

NP_446303

Cellular Locus

Cell Membrane | Sarcolemma

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide amino acids 189-205 of rat CavBeta2

Target

CavBeta2

Clonality

Monoclonal

Isotype

IgG1

Clone

N8b/1 (Formerly sold as S8B-1)

Conjugation

HRP

Validated Applications

WB,IHC,ELISA

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-332 was sufficient for detection of Cavβ2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Dolphin A.C. (2003) J Bioenerg. Biomembr. 35: 599-620. 2. Bichet D., et al. (2000) Neuron. 25: 177-190. 3. Xie M., et al. (2007) J Cell Biol. 178(3): 489-502.

Product Datasheet

https://cdn.gentaur.com/products/400/4289939/datasheet/smc-332d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4289939/msds/smc-332d-hrp.pdf

CAS Number

9007-83-4

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