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SHANK1 Antibody: RPE

Mouse Anti-Rat SHANK1 Monoclonal IgG1

Product Specifications

Background

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).

Specifications

Detects ~190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.

Product Name Alternative

GKAP/SAPAP interacting protein Antibody, OTTHUMP00000174437 Antibody, SH3 and multiple ankyrin repeat domains 1 Antibody, SH3 and multiple ankyrin repeat domains protein 1 Antibody, SH3/ankyrin domain gene 1 Antibody, SHAN1_HUMAN Antibody, SHANK 1 Antibody, Shank1 Antibody, Shank1a Antibody, Somatostatin receptor interacting protein Antibody, Somatostatin receptor-interacting protein Antibody, SPANK 1 Antibody, SPANK1 Antibody, SSTR interacting protein Antibody, SSTR-interacting protein Antibody, SSTRIP Antibody, Synamon Antibody

Synonyms

SHANK1 Antibody, Clone N22/21: RPE

UNSPSC

12352203

Gene ID

78957

Swiss Prot

Q9WV48

Accession Number

NP_113939.2

Cellular Locus

Cytoplasm | Cell Junction | Synapse | Postsynaptic Cell Membrane | Postsynaptic Density

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1

Target

SHANK1

Clonality

Monoclonal

Isotype

IgG1

Clone

N22/21 (Formerly sold as S22-21)

Conjugation

RPE

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-329 was sufficient for detection of Shank1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856. 2. Kim J.H., et al. (2009) Exp Mol Med. 41(4): 236-242. 3. Gong Y., et al. (2009) Brain Res. 1292: 191-198.

Product Datasheet

https://cdn.gentaur.com/products/400/4289867/datasheet/smc-329d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4289867/msds/smc-329d-rpe.pdf

CAS Number

9007-83-4

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