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TrpM7 Antibody: Biotin

Mouse Anti-Mouse TrpM7 Monoclonal IgG1

Product Specifications

Background

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants (1, 2).

Specifications

Detects ~220kDa in extracts of cells transiently transfected with TrpM7. No cross-reactivity against TrpM6.

Product Name Alternative

CHAK antibody, CHAK1 antibody, Channel kinase 1 antibody, Channel-kinase 1 antibody, Long transient receptor potential channel 7 antibody, LTrpC-7 antibody, LTRPC7 antibody, Transient receptor potential cation channel subfamily M member 7 antibody, TRP PLIK antibody, TRPM7 antibody, TRPM7_HUMAN antibody

Synonyms

TRPM7 Antibody, Clone S74: Biotin

UNSPSC

12352203

Gene ID

58800

Swiss Prot

Q923J1

Accession Number

NP_001157797.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1817-1863 (C- terminus) of mouse TrpM7

Target

TRPM7

Clonality

Monoclonal

Isotype

IgG1

Clone

S74

Conjugation

Biotin

Validated Applications

WB,IHC,ICC/IF |ELISA

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-316 was sufficient for detection of TrpM7 in 10 µg of COS cell lysate transiently transfected with TprM7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, and 9.55mM Sodium Bicarbonate in 95.45% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Brauchi S., Krapivinsky G., Krapivinsky L., Clapham D.E. (2008) Proc Natl Acad Sci USA. 105(24): 8304-8308. 2. Numata T, Okada Y. (2008) J Biol Chem. 283(22): 15097-15103.

Product Datasheet

https://cdn.gentaur.com/products/400/4289582/datasheet/smc-316d-bi.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4289582/msds/smc-316d-bi.pdf

CAS Number

9007-83-4

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