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Nav1.7 Antibody

Mouse Anti-Human Nav1.7 Monoclonal IgG1

Product Specifications

Background

Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).

Specifications

Detects ~230kDa. No cross-reactivity against other Nav channels.

Product Name Alternative

ETHA Antibody, hNE Na Antibody, NE NA Antibody, PN1 Antibody, SCN9A Antibody, voltage gated sodium channel subunit alpha Nav1 Antibody, peripheral sodium channel 1 Antibody, neuroendocrine sodium channel Antibody

Synonyms

Nav1.7 Antibody, Clone N68/6

UNSPSC

12352203

Gene ID

6335

Swiss Prot

Q15858

Accession Number

NP_002968.1

Cellular Locus

Membrane | Synapse

Host

Mouse

Species Reactivity

Human,Mouse,Rat,Hamster

Immunogen

Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7

Target

Nav1.7

Clonality

Monoclonal

Isotype

IgG1

Clone

N68/6 (Formerly sold as S68-6)

Conjugation

Unconjugated

Validated Applications

WB,IHC,ICC/IF,IP,AM

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-314 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. 2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.

Product MSDS

https://cdn.gentaur.com/products/400/4289520/msds/smc-314d.pdf

CAS Number

9007-83-4

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