KCNQ4 Antibody
Mouse Anti-Human KCNQ4 Monoclonal IgG1
Product Specifications
Background
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (1), particularly in sensory cells of the cochlea (2). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug (3).
Specifications
Detects ~77kDa.
Product Name Alternative
DFNA 2 antibody, DFNA2 antibody, KCNQ 4 antibody, Kcnq4 antibody, KCNQ4_HUMAN antibody, KQT like 4 antibody, KQT-like 4 antibody, KV7.4 antibody, Potassium channel KQT like 4 antibody, Potassium channel subunit alpha KvLQT4 antibody, Potassium voltage gated channel KQT like protein 4 antibody, Potassium voltage gated channel KQT like subfamily member 4 antibody, Potassium voltage gated channel subfamily KQT member 4 antibody, Potassium voltage-gated channel subfamily KQT member 4 antibody, Voltage gated potassium channel subunit Kv7.4 antibody, Voltage-gated potassium channel subunit Kv7.4 antibody
Synonyms
KCNQ4 Antibody, Clone N43/6
UNSPSC
12352203
Gene ID
9132
Swiss Prot
P56696
Accession Number
NP_004691.2
Cellular Locus
Plasma Membrane | Basal Cell Membrane
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein amino acids 2-77 of human KCNQ4
Target
KCNQ4
Clonality
Monoclonal
Isotype
IgG1
Clone
N43/6 (Formerly sold as S43-6)
Conjugation
Unconjugated
Validated Applications
WB,IHC,ICC/IF,AM
Purification
Protein G Purified
Limit Of Detection
1 µg/ml of SMC-309 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hernandez C.C., Zaiko O., Tolstykh G.P., Shapiro M.S. (2008) J Physiol. 586(7): 1811-1821.
2. Kharkovets T., et al. (2006) EMBO J. 25(3): 642-652.
3. Tatulian L., Delmas P., Abogadie F.C., Brown D.A. (2001) J Neuroscience. 21(15): 5535-5545.
Product MSDS
https://cdn.gentaur.com/products/400/4289419/msds/smc-309s.pdf
CAS Number
9007-83-4
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