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HCN1 Antibody: HRP

Mouse Anti-Rat HCN1 Monoclonal IgG1

Product Specifications

Background

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulatons of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain (1).

Specifications

Detects ~100kDa. No cross-reactivity against HCN2.

Product Name Alternative

BCNG-1 Antibody, BCNG1 Antibody, Brain cyclic nucleotide gated channel 1 Antibody, Brain cyclic nucleotide-gated channel 1 Antibody, HAC2 Antibody, HCN1 Antibody, HCN1_HUMAN Antibody, Hyperpolarization activated cyclic nucleotide gated potassium channel 1 Antibody, Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1 Antibody, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Antibody

Synonyms

HCN1 Antibody, Clone S70: HRP

UNSPSC

12352203

Gene ID

84390

Swiss Prot

Q9JKB0

Accession Number

NP_445827.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 778-910 (C terminus) of rat HCN1

Target

HCN1

Clonality

Monoclonal

Isotype

IgG1

Clone

S70

Conjugation

HRP

Validated Applications

WB,IHC,ELISA

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-304 was sufficient for detection of HCN1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232.

Product Datasheet

https://cdn.gentaur.com/products/400/4289289/datasheet/smc-304d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4289289/msds/smc-304d-hrp.pdf

CAS Number

9007-83-4

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