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Cav1.2 Antibody: HRP

Mouse Anti-Rabbit Cav1.2 Monoclonal IgG1

Product Specifications

Background

Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (1). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (2, 3) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (3).

Specifications

Detects ~240kDa (varies with cell background due to glycosylation).

Product Name Alternative

CACH3 Antibody, CACN4 Antibody, CACNA 1D Antibody, CACNL1A2 Antibody, voltage dependent L type calcium channel subunit alpha 1D Antibody, alpha-1 subunit voltage-dependent calcium channel Antibody, calcium channel voltage-dependent L type alpha 1C subunit1 Antibody, voltage-gated calcium channel alpha subunit Cav1.2 Antibody, calcium channel L type Antibody, alpha 1 polypeptide isoform 1 cardic muscle Antibody, calcium channel cardic dihydropyridine-sensitive alpha-1 subunit Antibody, voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit splice variant 10 Antibody, DHPR alpha-1 subunit Antibody, Voltage-gated calcium channel subunit alpha Cav1.2 Antibody, Calcium channel L type alpha-1 polypeptide isoform 1 cardiac muscle Antibody

Synonyms

Cav1.2 Antibody, Clone S57: HRP

UNSPSC

12352203

Gene ID

100101555

Swiss Prot

P15381

Accession Number

NP_001129994.1

Cellular Locus

Membrane | Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat,Hamster

Immunogen

Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2

Target

Cav1.2

Clonality

Monoclonal

Isotype

IgG1

Clone

S57

Conjugation

HRP

Validated Applications

WB,IHC,ELISA

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-300 was sufficient for detection of Cav1.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100), IP (1:200); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Splawski I., et al. (2004) Cell. 119 (1): 19-31. 2. Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3): 221a-222a. 3. Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.

Product Datasheet

https://cdn.gentaur.com/products/400/4289189/datasheet/smc-300d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4289189/msds/smc-300d-hrp.pdf

CAS Number

9007-83-4

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