PP5 Antibody
Mouse Anti-Human PP5 Monoclonal IgG1
Product Specifications
Background
Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues, potentially playing a role in the regulation of cell growth and differentiation. PP5 or PPT is predominantly a nuclear protein and interacts with CDC16 and CDC27. It is found in association with several proteins that influence intracellular signlaing-cascades intitiated by hormones (glucocorticoids) or cellular stress (hypoxia, oxidative stress and DNA Damage). It phosphorylates serine residues of skeletal muscle phosphorylase and histone H1. It may also be involved in mitosis and RNA biogenesis regulation (1,2).
CAS Number
9007-83-4
Specifications
Detects ~58kDa.
Product Name Alternative
PPP5 Antibody, PPT Antibody, Protein phosphatase T Antibody, Serine/threonine protein phosphatase 5 Antibody
Synonyms
PP5 Antibody, Clone 12F7
UNSPSC
12352203
Gene ID
5536
Swiss Prot
P53041
Accession Number
NP_006238.1
Cellular Locus
Nucleus | Cytoplasm
Host
Mouse
Species Reactivity
Human
Immunogen
Full length human PP5 protein
Target
PP5
Clonality
Monoclonal
Isotype
IgG1
Clone
12F7
Conjugation
Unconjugated
Validated Applications
WB,ICC/IF
Purification
Protein G Purified
Limit Of Detection
1 µg/ml of SMC-244 was sufficient for detection of PP5 in 15 µg of human A431 lysates by ECL analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Butzow R., et al. (1988) J Lab Clin Med. 111(2): 249-256.
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