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CENP-A Antibody: APC

Mouse Anti-Human CENP-A Monoclonal IgG1

Product Specifications

Background

A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome.

Specifications

Detects ~18kDa. Recognizes Human CENP-A.

Product Name Alternative

CENP A Antibody, cenpa Antibody, Centromere auto antigen A Antibody, Histone H3 like centromeric protein A Antibody

Synonyms

CENP-A Antibody, Clone 5A7-2E11: APC

UNSPSC

12352203

Gene ID

1058

Swiss Prot

P49450

Accession Number

NP_001035891.1

Cellular Locus

Nucleus | Chromosome | Centromere | Kinetochore

Host

Mouse

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a portion of human CENP-A

Target

CENPA

Clonality

Monoclonal

Isotype

IgG1

Clone

5A7-2E11

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-202 was sufficient for detection of CENPA in 20 µg of U2OS cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Rieder C.L., et al. (1998) Trends Cell Biol. 8: 310-318. 2. Choo K.H. (2000) Trends Cell Biol. 10: 182-188. 3. Muro Y., et al. (2000) Clin. Exp. Immunol. 120: 218-223. 4. Howman E.V., et al. (2000) Proc. Natl. Acad. Sci. USA 97: 1148-1153.

Product Datasheet

https://cdn.gentaur.com/products/400/4288096/datasheet/smc-202d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4288096/msds/smc-202d-apc.pdf

CAS Number

9007-83-4

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