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MDC1 Antibody

Mouse Anti-Mouse MDC1 Monoclonal IgG1

Product Specifications

Background

MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.

Specifications

Detects ~184kDa. This antibody recognizes MDC1 at and around the N-terminus.

Product Name Alternative

Nuclear factor with BRCT domains1 Antibody, mediator of DNA damage checkpoint 1 Antibody

Synonyms

MDC1 Antibody, Clone P2B11

UNSPSC

12352203

Gene ID

240087

Swiss Prot

Q5PSV9

Accession Number

NP_001010833.2

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

Human,Mouse,Bovine,Chimpanzee

Immunogen

GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus

Target

MDC1

Clonality

Monoclonal

Isotype

IgG1

Clone

P2B11

Conjugation

Unconjugated

Validated Applications

WB,ICC/IF

Purification

Protein G Purified

Limit Of Detection

0.5 µg/ml of SMC-197 was sufficient for detection of MDC1 in 10 µg of HeLa cell lysate by ECL immunoblot analysis.

Concentration

1 mg/ml

Dilution

WB (1:2000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Lou Z., et al. (2004) J Biol Chem. 279(45): 46359-46362. 2. Luo K., Yuan J, Lou Z. (2011) J Biol Chem. 286(32): 28192-28199. 3. Strauss C., Halevy T., Macarov M., Argaman L., and Goldbery M. (2011) DNA Repair (Amst.). 10(8): 806-814. 4. Wilson K.A., et al. (2011) Mol Cancer Res. 9(6): 766-781.

Product MSDS

https://cdn.gentaur.com/products/400/4288010/msds/smc-197s.pdf

CAS Number

9007-83-4

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