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MDC1 Antibody: APC

Mouse Anti-Mouse MDC1 Monoclonal IgG1

Product Specifications

Background

MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.

Specifications

Detects ~184kDa. This antibody recognizes MDC1 at and around the N-terminus.

Product Name Alternative

Nuclear factor with BRCT domains1 Antibody, mediator of DNA damage checkpoint 1 Antibody

Synonyms

MDC1 Antibody, Clone P2B11: APC

UNSPSC

12352203

Gene ID

240087

Swiss Prot

Q5PSV9

Accession Number

NP_001010833.2

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

Human,Mouse,Bovine,Chimpanzee

Immunogen

GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus

Target

MDC1

Clonality

Monoclonal

Isotype

IgG1

Clone

P2B11

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

0.5 µg/ml of SMC-197 was sufficient for detection of MDC1 in 10 µg of HeLa cell lysate by ECL immunoblot analysis.

Concentration

1 mg/ml

Dilution

WB (1:2000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Lou Z., et al. (2004) J Biol Chem. 279(45): 46359-46362. 2. Luo K., Yuan J, Lou Z. (2011) J Biol Chem. 286(32): 28192-28199. 3. Strauss C., Halevy T., Macarov M., Argaman L., and Goldbery M. (2011) DNA Repair (Amst.). 10(8): 806-814. 4. Wilson K.A., et al. (2011) Mol Cancer Res. 9(6): 766-781.

Product Datasheet

https://cdn.gentaur.com/products/400/4287996/datasheet/smc-197d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4287996/msds/smc-197d-apc.pdf

CAS Number

9007-83-4

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