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DUX4 Antibody: PerCP

Mouse Anti-Human DUX4 Monoclonal IgG1

Product Specifications

Background

DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).

Specifications

Detects ~45kDa. No cross-reactivity with DUX4c.

Product Name Alternative

Double homeobox 4 Antibody, Double homeobox 10 Antibody, DUX10 Antibody, Double homeobox protein 4/10 Antibody, DUX4L antibody, DUX4L1 antibody

Synonyms

DUX4 Antibody, Clone P2B1: PerCP

UNSPSC

12352203

Gene ID

22947

Swiss Prot

F5GZ66

Accession Number

NP_149418.3

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

Human,Mouse

Immunogen

C-terminal 76 amino acids of Human DUX4 with glutathione-s-transferase (gst) tag

Target

DUX4

Clonality

Monoclonal

Isotype

IgG1

Clone

P2B1

Conjugation

PerCP

Validated Applications

WB,IHC,ICC/IF,ELISA

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-192 was sufficient for detection of DUX4 in 20 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-mouse IgG: HRP as teh secondary.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Entrez Gene: “Dux4 Double Homeobox, 4” 2. Dixit M., et al., (2007) Proc. Natl Acad Sci. USA. 104(46): 18157-18162. 3. Kowaljow V., et al. (2007) Neuromuscl Disord. 17(8): 611-623. 4. Lemmers R., et al. (2010) Science Express. 329(5999): 1650-1653. 5. Snider L., et al. (2010) PLoS Genetics. 6:1-14.

Product Datasheet

https://cdn.gentaur.com/products/400/4287882/datasheet/smc-192d-pcp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4287882/msds/smc-192d-pcp.pdf

CAS Number

9007-83-4

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