Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

DUX4 Antibody: ATTO 488

Mouse Anti-Human DUX4 Monoclonal IgG1

Product Specifications

Background

DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).

Specifications

Detects ~45kDa. No cross-reactivity with DUX4c.

Product Name Alternative

Double homeobox 4 Antibody, Double homeobox 10 Antibody, DUX10 Antibody, Double homeobox protein 4/10 Antibody, DUX4L antibody, DUX4L1 antibody

Synonyms

DUX4 Antibody, Clone P2B1: ATTO 488

UNSPSC

12352203

Gene ID

22947

Swiss Prot

F5GZ66

Accession Number

NP_149418.3

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

Human,Mouse

Immunogen

C-terminal 76 amino acids of Human DUX4 with glutathione-s-transferase (gst) tag

Target

DUX4

Clonality

Monoclonal

Isotype

IgG1

Clone

P2B1

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-192 was sufficient for detection of DUX4 in 20 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-mouse IgG: HRP as teh secondary.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Entrez Gene: “Dux4 Double Homeobox, 4” 2. Dixit M., et al., (2007) Proc. Natl Acad Sci. USA. 104(46): 18157-18162. 3. Kowaljow V., et al. (2007) Neuromuscl Disord. 17(8): 611-623. 4. Lemmers R., et al. (2010) Science Express. 329(5999): 1650-1653. 5. Snider L., et al. (2010) PLoS Genetics. 6:1-14.

Product Datasheet

https://cdn.gentaur.com/products/400/4287863/datasheet/smc-192d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4287863/msds/smc-192d-a488.pdf

CAS Number

9007-83-4

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Human ATP5F1 Protein
B2011812 100 µg

Human ATP5F1 Protein

Ask
View Details
Rabbit Polyclonal ZNF821 Antibody [DyLight 350]
NBP2-82055UV 0.1 mL

Rabbit Polyclonal ZNF821 Antibody [DyLight 350]

Ask
View Details
Rat anti Mouse IL6 monoclonal antibody
CABT-BL8440 100ug

Rat anti Mouse IL6 monoclonal antibody

Ask
View Details
Rab43 (NM_001039394) Mouse Tagged ORF Clone
MG216803 10 µg

Rab43 (NM_001039394) Mouse Tagged ORF Clone

Ask
View Details
Influenza A/Greylag_goose/Scotland/024915/2022 (EPI_ISL_13486869) neuraminidase (EPI2076372)
REC32061-100 1 Each

Influenza A/Greylag_goose/Scotland/024915/2022 (EPI_ISL_13486869) neuraminidase (EPI2076372)

Ask
View Details
ZBP-89 (D-10)
sc-137170 200 µg/mL

ZBP-89 (D-10)

Ask
View Details