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DUX4 Antibody: ATTO 390

Mouse Anti-Human DUX4 Monoclonal IgG1

Product Specifications

Background

DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).

Specifications

Detects ~45kDa. No cross-reactivity with DUX4c.

Product Name Alternative

Double homeobox 4 Antibody, Double homeobox 10 Antibody, DUX10 Antibody, Double homeobox protein 4/10 Antibody, DUX4L antibody, DUX4L1 antibody

Synonyms

DUX4 Antibody, Clone P2B1: ATTO 390

UNSPSC

12352203

Gene ID

22947

Swiss Prot

F5GZ66

Accession Number

NP_149418.3

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

Human,Mouse

Immunogen

C-terminal 76 amino acids of Human DUX4 with glutathione-s-transferase (gst) tag

Target

DUX4

Clonality

Monoclonal

Isotype

IgG1

Clone

P2B1

Conjugation

ATTO 390

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-192 was sufficient for detection of DUX4 in 20 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-mouse IgG: HRP as teh secondary.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Entrez Gene: “Dux4 Double Homeobox, 4” 2. Dixit M., et al., (2007) Proc. Natl Acad Sci. USA. 104(46): 18157-18162. 3. Kowaljow V., et al. (2007) Neuromuscl Disord. 17(8): 611-623. 4. Lemmers R., et al. (2010) Science Express. 329(5999): 1650-1653. 5. Snider L., et al. (2010) PLoS Genetics. 6:1-14.

Product Datasheet

https://cdn.gentaur.com/products/400/4287862/datasheet/smc-192d-a390.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4287862/msds/smc-192d-a390.pdf

CAS Number

9007-83-4

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