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Piccolo Antibody: RPE

Mouse Anti-Human Piccolo Monoclonal IgG2b Kappa

Product Specifications

Background

Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).

Specifications

Detects ~550kDa. No cross-reactivity to Bassoon.

Product Name Alternative

ACZ Antibody, Aczonin Antibody, PCLO Antibody, Pico Antibody, presynaptic cytomatrix protein Antibody

Synonyms

Piccolo Antibody, Clone 6H9-B6: RPE

UNSPSC

12352203

Gene ID

26875

Swiss Prot

Q9QYX7

Accession Number

NP_001104266.1

Cellular Locus

Cell Junction | Synapse

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Human full length recombinant protein (GenBank ID: BC001304.1)

Target

Piccolo

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

6H9-B6

Conjugation

RPE

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-188 was sufficient for detection of Piccolo in 20 µg of rat brain tissue lysate by colorimetric immunoblot analysis using goat IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619. 2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162. 3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038-6047.

Product Datasheet

https://cdn.gentaur.com/products/400/4287833/datasheet/smc-188d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4287833/msds/smc-188d-rpe.pdf

CAS Number

9007-83-4

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