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Acetylated Lysine Antibody: APC

Mouse Anti- Acetylated Lysine Monoclonal IgG1

Product Specifications

Background

Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε development (5).

Specifications

Detects proteins containing acetylated lysine residues in ELISA and western blots. Does not detect non-acetylated lysine residues.

Product Name Alternative

Acetyl Lysine Antibody, Acetylated lysine Antibody, Lysine Antibody

Synonyms

Acetylated Lysine Antibody, Clone 7F8: APC

UNSPSC

12352203

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

Species Independent

Immunogen

Acetylated KLH

Target

Acetylated Lysine

Clonality

Monoclonal

Isotype

IgG1

Clone

7F8

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg of SMC-153 was sufficient to detect acetylated chicken erythrocyte histones (sodium butyrate-treated) using 20 µg total protein, on western blot by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Yang XJ. (2005). Oncogene. 24:1653-1662. 2. Hassig, C.A. and Schreiber, S.L. (1997). Curr. Opin. Chem. Biol. 1(3): 300-308. 3. Yang XJ. (2004). Bioessays 26:1076-1087. 4. Hughes, R.E. (2002). Curr. Biol. 12: R141-R143. 5. Vigushin, D.M. and Coombes, R.C. (2004). Curr. Cancer Drug Targets 4: 205-218.

Product Datasheet

https://cdn.gentaur.com/products/400/4286996/datasheet/smc-153d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4286996/msds/smc-153d-apc.pdf

CAS Number

9007-83-4

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