TGIF2 Polyclonal Antibody

TGIF2 (TGFB Induced Factor Homeobox 2) is a Protein Coding gene. Diseases associated with TGIF2 include Holoprosencephaly 4. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and mir34a and TGIF2 in osteoclastogenesis. The protein encoded by TGIF2 is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. TGIF2 is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between TGIF2 and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.

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Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000