PLXD1 Polyclonal Antibody

PLXND1 (Plexin D1) is a Protein Coding gene. Diseases associated with PLXND1 include Moebius Syndrome and Conotruncal Heart Malformations. Among its related pathways are Developmental Biology and Semaphorin interactions. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNB1. Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity) . Mediates anti-angiogenic signaling in response to SEMA3E.

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Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000