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MEISi-1

MEISi-1 is a homeodomain inhibitor of small molecule MEIS1 protein. MEISi-1 significantly inhibited the activity of luciferase reporter genes containing MEIS binding sites (TGACAG) and induced self-renewal of mouse and human HSCS in vitro and in vivo. MEISi-1 can be used for research in blood diseases, heart regeneration and cancer[1].

Product Specifications

CAS Number

[446306-43-0]

UNSPSC

12352005

Target

HOXA

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease; Others

Assay Protocol

https://www.medchemexpress.com/meisi-1.html

Purity

98.76

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(C)=C1C)C2=CC=C(OCC(NCC3=CC=CC=C3)=O)C=C2

Molecular Formula

C24H24N2O3

Molecular Weight

388.46

References & Citations

[1]Turan R D, et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity[J]. Scientific reports, 2020, 10 (1) : 7994.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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