HCN4 Polyclonal Antibody

Rabbit Anti-HCN4 Polyclonal Antibody

Product Specifications

Background

HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in HCN4 have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15.

CAS Number

9007-83-4

Product Name Alternative

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Gene ID

10021

Accession Number

Q9Y3Q4

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from part region of human HCN4 protein at amino acid sequence of 600-680

Clonality

Polyclonal

Tag

HCN4

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

132kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of HCN4 protein

Observed Molecular Weight

132

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000