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Gremlin-2 Polyclonal Antibody

Rabbit Anti-Gremlin-2 Polyclonal Antibody

Product Specifications

Background

Gremlin-2 encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which Gremlin-2 belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, Gremlin-2 may play a role in regulating organogenesis, body patterning, and tissue differentiation.

Product Name Alternative

Gremlin-2; Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus

Gene ID

64388

Accession Number

Q9H772

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from part region of human Gremlin-2 protein at amino acid sequence of 71-120

Clonality

Polyclonal

Tag

Gremlin-2

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

19kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of Gremlin-2

Product Datasheet

https://www.abbkine.com/datasheet/ABP58712.pdf

Observed Molecular Weight

19

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:500-200; ELISA 1:10000-20000; IF 1:50-200

Other Product Names

Gremlin-2; Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q9H772

CAS Number

9007-83-4

Isotype

Rabbit IgG

Available Sizes

Curated Selection

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