ASPM Polyclonal Antibody

Rabbit Anti-ASPM Polyclonal Antibody

Product Specifications

Background

ASPM is the human ortholog of the Drosophila melanogaster ‘abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene. ASPM (Abnormal Spindle Microtubule Assembly) is a Protein Coding gene. Diseases associated with ASPM include Microcephaly 5, Primary, Autosomal Recessive and Primary Microcephaly.

CAS Number

9007-83-4

Product Name Alternative

Abnormal spindle-like microcephaly-associated protein; Abnormal spindle protein homolog; Asp homolog

Gene ID

259266

Accession Number

Q8IZT6

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from part region of human ASPM protein at amino acid sequence of 1230-1310

Clonality

Polyclonal

Tag

ASPM

Applications

IHC, IF

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

382kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of ASPM protein

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300; IF 1:50-200