O, p'-DDE

O, p'-DDE (2,4-Dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass, and in sediments from DDT manufacturing plants around the Huntsville Spring Branch-Indian Creek tributary system, where it becomes a persistent organic pollutant (POP) . o, p'-DDE inhibits the binding of estrogens to the rainbow trout estrogen receptor (rtER) with an IC50 value of 3.2 μM. o, p'-DDE also induces estradiol secretion from isolated granulosa and theca cells of porcine ovarian follicles in a concentration-dependent manner. o, p'-DDE treatment increases follicle degeneration and reduces testis size in Japanese medaka (O. latipes) [1].

Product Specifications

CAS Number

[3424-82-6]

Product Name Alternative

2,4'-DDE; 2,4-Dichlorodiphenyldichloroethylene; 2,4'-DDE; o, p'-Dichlorodiphenyldichloroethylene

UNSPSC

12352005

Hazard Statement

H225-H301+H311+H331-H302-H351-H370-H410

Target

Insecticide

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/o-p-dde.html

Smiles

ClC1=CC=C(C=C1)/C(C2=CC=CC=C2Cl)=C(Cl)/Cl

Molecular Formula

C14H8Cl4

Molecular Weight

318.03

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P273-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P391-P403+P233-P403+P235-P405-P501

References & Citations

[1]Matthews, et al. Differential estrogen receptor binding of estrogenic substances: A species comparison. J. Steroid. Biochem. Mol. Biol. 74 (4), 223-234 (2000) .