ASC-1 Polyclonal Antibody

Rabbit Anti-ASC-1 Polyclonal Antibody

Product Specifications

Background

TRIP4 (thyroid hormone receptor interactor 4) encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in TRIP4 are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1) .

CAS Number

9007-83-4

Product Name Alternative

TRIP4; Activating signal cointegrator 1; ASC-1; Thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP-4

Gene ID

9325

Accession Number

Q15650

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from the Internal region of human ASC-1 at AA range: 50-130

Clonality

Polyclonal

Tag

Activating signal cointegrator 1

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

66kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

ASC-1 Polyclonal Antibody detects endogenous levels of ASC-1 protein.

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.