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TDG Polyclonal Antibody

Rabbit Anti-TDG Polyclonal Antibody

Product Specifications

Background

The protein encoded by TDG (thymine DNA glycosylase) belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. TDG may have a pseudogene in the p arm of chromosome 12.

CAS Number

9007-83-4

Product Name Alternative

TDG; G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase

Gene ID

6996

Accession Number

Q13569

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from the Internal region of human TDG at AA range: 1-80

Clonality

Polyclonal

Tag

G

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

46kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

TDG Polyclonal Antibody detects endogenous levels of TDG protein.

Observed Molecular Weight

46

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.

Other Product Names

TDG; G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q13569

Isotype

Rabbit IgG

Available Sizes

Curated Selection

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