5-PAHSA

5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics[1][2][3].

Product Specifications

CAS Number

[1481636-41-2]

Product Name Alternative

trans-PX-102,(-)-PX-102 (trans isomer); (-)-PX-104,PX-111,ABR-215757-d5-1; ABR 25757-d5-1

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H331-H336-H351-H361-H372-H412

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-pahsa.html

Concentration

10mM

Purity

98.08

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

OC(CCCC(CCCCCCCCCCCCC)OC(CCCCCCCCCCCCCCC)=O)=O

Molecular Formula

C34H66O4

Molecular Weight

538.89

Precautions

P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wang JT, et al. A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS Neurosci Ther. 2021 Apr;27 (4) :484-496.|[2]Paluchova V, et al. Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice. Diabetes. 2020 Mar;69 (3) :300-312. |[3]Wang YM, et al. High Glucose Concentration Impairs 5-PAHSA Activity by Inhibiting AMP-Activated Protein Kinase Activation and Promoting Nuclear Factor-Kappa-B-Mediated Inflammation. Front Pharmacol. 2019 Jan 7;9:1491.