DOCK 180 Polyclonal Antibody

Rabbit Anti-DOCK 180 Polyclonal Antibody

Product Specifications

Background

DOCK1 encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. Dedicator of cytokinesis protein 1 regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants.

CAS Number

9007-83-4

Product Name Alternative

DOCK1; Dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOCK180

Gene ID

1793

Accession Number

Q14185

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from the C-terminal region of human DOCK 180 at AA rangle: 1630-1710

Clonality

Polyclonal

Tag

Dedicator of cytokinesis protein 1

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

215kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

DOCK 180 Polyclonal Antibody detects endogenous levels of DOCK 180 protein.

Observed Molecular Weight

215

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.