PDE10A Polyclonal Antibody

Rabbit Anti-PDE10A Polyclonal Antibody

Product Specifications

Background

The phosphodiesterase 10A encoded by PDE10A belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for PDE10A.

CAS Number

9007-83-4

Product Name Alternative

PDE10A; cAMP and cAMP-inhibited cGMP 3'; 5'-cyclic phosphodiesterase 10A

Gene ID

10846

Accession Number

Q9Y233

Reactivity

Human, Rat

Immunogen

Synthesized peptide derived from the N-terminal region of human PDE10A at AA rangle: 40-120

Clonality

Polyclonal

Tag

CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Applications

WB, ELISA, IHC

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

75kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

PDE10A Polyclonal Antibody detects endogenous levels of PDE10A protein.

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000