MGluR5 Polyclonal Antibody

Rabbit Anti-mGluR5 Polyclonal Antibody

Product Specifications

Background

GRM5 encodes a member of the G-protein coupled receptor 3 protein family. Metabotropic glutamate receptor 5 is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. Metabotropic glutamate receptor 5 may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.

CAS Number

9007-83-4

Product Name Alternative

GRM5; GPRC1E; MGLUR5; Metabotropic glutamate receptor 5; mGluR5

Gene ID

2915

Accession Number

P41594

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from the N-terminal region of human mGluR5 at AA range: 40-120

Clonality

Polyclonal

Tag

Metabotropic glutamate receptor 5

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

130kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

MGluR5 Polyclonal Antibody detects endogenous levels of mGluR5 protein.

Observed Molecular Weight

130

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.