SEPT4 rabbit pAb

Septin 4 (SEPT4) Homo sapiens This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010],

Product Specifications

Background

UniProt

O43236

Swiss Prot

O43236

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

52kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

52kD

Fragment

IgG

Subcellular Location

Cytoplasm . Cell projection, cilium, flagellum . Cytoplasmic vesicle, secretory vesicle . Cell projection, axon . Cell projection, dendrite . Perikaryon . Cell junction, synapse . In platelets, found in areas surrounding alpha-granules (PubMed:15116257) . Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (PubMed:25588830) . Expressed and colocalized with SLC6A3 and SNCA in axon terminals, especially at the varicosities (By similarity) . .; [Isoform ARTS]: Mitochondrion . Nucleus . While predominantly localized in the mitochondria under resting conditions, translocates into the nucleus after TGF-beta treatment and apoptosis induction. .